Polimorfismo genético de interleuquina-1: Asociación con cáncer gástrico en la población de alto riesgo del Centroccidente de Venezuela

• Miryan Cañas ^[1] ; Yeinmy Morán ; María Belén Rivero ^[1] ; Adolfo Bohórquez ^[2] ; Venus Villegas ^[2] ; Yanet Rendón ^[2] ; Eddy Ramírez ^[2] ; Elvis Valderrama ^[3] ; Zuly Briceño ^[1] ; Miguel Ángel Chiurillo ^[1]
  1. [1] Universidad Centroccidental Lisandro Alvarado

     Universidad Centroccidental Lisandro Alvarado

     Venezuela

     
  2. [2] Hospital Antonio María Pineda-UCLA Servicio de Gastroenterología
  3. [3] Hospital Antonio María Pineda-UCLA Departamento de Anatomía Patológica

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• Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 137, Nº. 1, 2009, págs. 63-70
• Idioma: español
• Títulos paralelos:
  • lnterleukin-1 genetic polymorphism: Association with gastric cancer in the high-risk Central-Western population of Venezuela
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• Resumen

  • Background: Genetic predisposition may playa role in the prevalence of gastric cancer (GC). Aim: To investígate the relationship between selected interleukin-1 (IL-1) loci polymorphisms and gastric cancer risk in the Central-Western región of Venezuela, where gastric cancer represents the first cause of cancer-related deaths. Material and methods: In a case-control study we compared the frequencies of IL-1B-511 and IL-1B+3954 biallelic polymorphism, and the pentallelic VNTR of IL-IRN in 84 gastric adenocarcinoma parafñn-embedded biopsies and 84 endoscopic biopsies from cancer-free controls. Results: No significant increase in genotypic frequencies in gastric cancer was observed for any ofthe IL-1B-511 allelic combinations. However, in a logistic regression analysis, a significant association emerged for the IL-1B+3954C carrier genotype (odds ratio (OR): 6.2; 95% confidence intervals (CI) 1.3-28.8). On the other hand, a significantly higherrisk was evidenced for the IL-IRN*2/*2genotype (OR: 7.0; 95% CI2.3-21.5). Onlypatients with a well/moderately-differentiated adenocarcinoma that were homozygotes for the E-IRN*2/*2 genotype, liad a higher risk than the complete gastric cancer group (OR: 8.1, 95% CI 2.5-26.8). Some genotype combinations among IL-1B-511, IL-1B+3954 and IL-IRN showed an increased risk for developing gastric cancer and well/moderate differentiated adenocarcinoma, that was dependent ofthe presence of IL-IRN*2/*2 genotype. Conclusions: IL-IRN*2/*2 genotype is associated with increased risk of gastric cancer in the Venezuelan population.