Influencia del estado nutricional, niveles hormonales séricos e historia familiar de cáncer en el desarrollo del cáncer de mama

• Emilio González Jiménez ^[1] ; Pedro A García López ^[1] ; Jacqueline Schmidt-Río-Valle ^[1] ; Carmen Valenza ^[1]
  1. [1] Universidad de Granada

     Universidad de Granada

     Granada, España

     
• Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 140, Nº. 10, 2012, págs. 1263-1267
• Idioma: español
• Títulos paralelos:
  • Influence of nutritional status, hormones serum levels, and family history on breast cancer development
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• Resumen

  • Background: Several studies have analyzed the relation between obesity and the hormonal imbalances generated by overweight and a family history of breast cancer. All of these factors are potentially implicated in the early development of breast cancer. Aim: To verify the existence of a significant relation between the nutritional status of breast cancer patients, their hormone serum levels (estrogens, prolactin, and progesterone), and the existence of a family history of breast cancer. Material and Methods: Retrospective data was collected from clinical records of524 women diagnosed with breast cancer in a Spanish hospital. Results: There was a positive association between estrogen, progesterone and prolactin serum levels and body mass index. The elevations in hormone levels occurred earlier in life among women with a family history of breast cancer. A two way ANOVA found a significant association between progesterone and prolactin levels with the age at diagnosis of breast cancer. Conclusions: Extreme serum levels of these hormones appear to be related to the early development of breast cancer, which in turn is influenced by the existence of a family history of cancer among those women with normal or average hormone levels.