Asociación entre polimorfismos del gen de adiponectina y estado nutricional en escolares de la comuna de Hualpén
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Gloria Orellana [1] ; Jorge Sapunar [2] ; Katia Sáez [1] ; Claudio Aguayo [1] ; Carlos Calvo [1] ; Claudia Radojkovic [1] ; Benilde Riffo [1] ; Andrea Gleisner [1] ; Sylvia Asenjo [1] ; Natalia Ulloa [1]
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[1] Universidad de Concepción
Universidad de Concepción
Comuna de Concepción, Chile
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[2] Universidad de La Frontera
Universidad de La Frontera
Temuco, Chile
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- Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 140, Nº. 10, 2012, págs. 1245-1252
- Idioma: español
- Títulos paralelos:
- Association between adiponectin gene polymorphisms and obesity in school age children from Hualpén, Chile
- Enlaces
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Resumen
Background: Several genetic polymorphisms of adiponectin have been associated to metabolic diseases as obesity and co-morbidities. Aim: To investigate if there are associations between +45TG, +276GT, -11,377CG y -11,391GA adiponectin SNPs (single nucleotide polymorphism) with obesity in a Chilean children population. Material and Methods: A case-control study was performed in 241 obese and 126 normal weight children (7-11 years old) from the urban community of Hualpén, Biobío region. Children were classified as normal or obese, according to age and gender-specificpercentiles defined by Centerfor Disease Control and Prevention (CDC). The analysis of serum markers was carried out using commercial kits. Adiponectin polymorphisms were determined through a High Resolution Melting (HRM)-enabled real time PCR and by DNA fragment sequencing. Results: The observed allelic frequencies of the studied SNPs were over 11%. The 11,377CG polymorphism was associated with a high risk of obesity, calculated by the additive inheritance model (odds ratio = 1.389, 95% confidence interval: 1.001-1.929,p = 0.049). Conclusions: Obese school children of the Biobío Region, have an increased risk of carrying the susceptibility allele polymorphism 11377CG of adiponectin gene.
