Impacto clínico de la influenza A H1N1 pandémica en el hospital de Puerto Montt, Chile

• Raúl Riquelme O ^[2] ; Mauricio Riquelme O ^[2] ; María Luisa Rioseco Z ^[3] ; Carlos Inzunza P ^[2] ; Cristian Contreras G ^[1] ; Yarella Gómez V ^[1] ; Javier Riquelme D ^[1]
  1. [1] Universidad San Sebastián

     Universidad San Sebastián

     Comuna de Concepción, Chile

     
  2. [2] Hospital de Puerto Montt Servicio de Medicina Enfermedades Respiratorias
  3. [3] Hospital de Puerto Montt Laboratorio de Microbiología

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• Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 139, Nº. 3, 2011, págs. 321-326
• Idioma: español
• Títulos paralelos:
  • Clinical impact of pandemic influenza A H1N1 in a Chilean regional hospital
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• Resumen

  • Background: Pandemic flu (H1N1 ) strongly affected southern Chile during2009. Aim: To report the logistic and organizational changes implemented at a regional hospital to face the pandemic. Material and Methods: All patients with flu like disease that were hospitalized, were prospectively enrolled at the Puerto Montt hospital. A nasopharyngeal aspirate was obtained in all for influenza virus A and B direct immunofluorescence and polymerase chain reaction (PCR). All epidemiological and clinical data of patients were recorded. Results: Between May 29 and July 7, 2009, 184 adults were admitted to the hospital and in 117patients aged 41 ± 18 years (56% females ), direct immunofluorescence was positive for influenza. In 67 of these patients PCR did not confirm the disease. These unconfirmed patients had a mean age of 49 ± 19 years (p < 0.01, compared with confirmed cases) and had a lower frequency of fever, rhinorrhea and chills. No significant differences in the incidence of community acquired pneumonia or chest X ray findings were observed between confirmed and unconfirmed cases. Hospital stay was over 15 days in 14% of confirmed cases and 5% of unconfirmed cases (p = 0.03). Fifteen patients, aged 53 ± 18 years, died. Conclusions: Low sensibility of direct immunofluorescence and delay in obtaining PCR confirmation of influenza posed a problem for the management of these patients.