Histiocitosis de células de Langerhans pulmonar: Caso clínico

• RODRIGO OSSES A ^[1] ; SERGIO GONZÁLEZ B ^[1] ; MARCIA AGUIRRE Z ^[2] ; FERNANDO SALDÍAS P ^[1]
  1. [1] Pontificia Universidad Católica de Chile

     Pontificia Universidad Católica de Chile

     Santiago, Chile

     
  2. [2] Hospital Regional de Antofagasta

     Hospital Regional de Antofagasta

     Antofagasta, Chile

     
• Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 139, Nº. 2, 2011, págs. 230-235
• Idioma: español
• Títulos paralelos:
  • Adult pulmonary Langerhans cell histiocytosis: Report of one case
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• Resumen

  • Adult pulmonary Langerhans cell histiocytosis (PLCH) is a rare disorder of unknown etiology that occurs predominantly in young smokers, with an incidence peak at 20-40 years of age. In adults, pulmonary involvement with Langerhans cell histiocytosis usually occurs as a single-organ disease and is characterized by focal Langerhans cell granulomas infiltrating and destroying distal bronchioles. We report a 23-year-old asymptomatic male smoker with a non specific interstitial infiltrate found in preventive chest X ray examination. A high resolution chest CT scan showed multiple cystic structures predominating in the upper lobes, with small centrilobular nodules. A transbronchial biopsy showed a lymphocytic lung infiltrate with Langerhans cells. A surgical biopsy confirmed the diagnosis of pulmonary Langerhans cell histiocytosis. After six months of follow up, the patient is in good conditions.