Linfomas asociados a infección por Virus de Inmunodeficiencia Humana: Experiencia de un centro hospitalario de la V región, Chile

• CHRISTINE ROJAS H ^[2] ; CARLOS MERINO M ^[2] ; JUAN PABLO GHIRINGHELLI M ^[1] ; JOSÉ RAMÓN RODRÍGUEZ A ^[1] ; FELIPE MARTÍNEZ L ^[2] ; WERNER JENSEN R ^[3]
  1. [1] Universidad de Valparaíso

     Universidad de Valparaíso

     Valparaíso, Chile

     
  2. [2] Hospital Gustavo Fricke Servicio de Medicina Interna Unidad de Hematología
  3. [3] Hospital Gustavo Fricke Servicio de Medicina Interna Unidad de Infectología

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• Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 139, Nº. 1, 2011, págs. 27-35
• Idioma: español
• Títulos paralelos:
  • Lymphomas associated with human immunodeficiency virus infection: Retrospective review of medical records
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• Resumen

  • Background: The incidence oflymphoma increases enormously inpatients infecten with the human immunodeficiency virus (HIV). Aim: To describe the incidence, clinical and histológica! characteristics, treatments and survival of lymphomas associated with HTV infection. Material and Methods: Retrospective review of medical records ofpatients with HIV and lymphoma, treated in a public hospital, between January 2001 and June 2009. Results: Twenty-two mole patients were included but 14 had immunohistochemical confirmation ofthe lymphoma. The accumulated incidence for thisperiod was 2.8%. The median age at lymphoma diagnosis was 39.5 years. Twelvepatients (86%) had non-Hodgkin lymphoma (NHI) and two (14%) Hodgkin lymphoma. The main pathological type of non-Hodgkin lymphomas was diffuse large B cell in seven cases (50%). The mean CD4 cell count and viral load were 83 cell/mm³ (33.5-113.5) and 26.000 RNA copies/ml (1210-196500), respectively Twelve patients (86%) had B type symptoms of lymphoma at the moment of diagnosis. Eleven patients (29%) received chemotherapy with or without radiotherapy, onepatient (7%) received radiotherapy alone and two patients (14%) received palliative symptomatic treatment. Six cases (43%) received highly active antiretroviral therapy simultaneously with chemotherapy. Global mortality in this series was 57% (8patients) with a median survival time of 5.8 months (2.6-26.2). Conclusions: In this series ofpatients infected with HIV, a predominance of aggressive histológica! subtypes of lymphomas and low complete remission rates, were observed.