Relación colesterol total a HDL y colesterol no HDL: los mejores indicadores lipídicos de aumento de grosor de la íntima media carotidea

Mónica Acevedo; Verónica Krämer; Rodrigo Tagle; Ramón Corbalán; Pilar Arnáiz Gómez; Ximena Berríos; Carlos Navarrete

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Relación colesterol total a HDL y colesterol no HDL: los mejores indicadores lipídicos de aumento de grosor de la íntima media carotidea

Mónica Acevedo ^[1] ; Verónica Krämer ^[1] ; Rodrigo Tagle ^[1] ; Ramón Corbalán ^[1] ; Pilar Arnaíz ^[1] ; Ximena Berríos ^[1] ; Carlos Navarrete ^[2]
1. [1] Pontificia Universidad Católica de Chile
  
  Pontificia Universidad Católica de Chile
  
  Santiago, Chile
2. [2] Universidad de La Serena
  
  Universidad de La Serena
  
  La Serena, Chile
Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 140, Nº. 8, 2012, págs. 969-976
Idioma: español
Títulos paralelos:
- Total/HDL cholesterol ratio and non HDL cholesterol as predictors for increased intima media thickness
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Resumen
- Background: LDL, HDL cholesterol and triglycerides, are the most commonly used lipid cardiovascular risk predictor indicators. However population based studies have shown that non-HDL cholesterol and total/HDL cholesterol ratio are better predictors, are easy to measure and do not require fasting. Aim: To determine which lipid indicators are better determinants of subclinical atherosclerosis, measured by intima media thickness (IMT) among subjects without demonstrated atherosclerosis. Material and Methods: Lipid profile, height, weight, blood pressure and bilateral IMT, measured by ultrasound with automatic border recognition software, were assessed in 770 men and 854 women aged 45 ± 11 years, in Santiago de Chile. Results: Mean total cholesterol was 202, HDL 50, LDL 121, triglycerides 157 and non-HDL cholesterol 152 mg/dl. Total/HDL cholesterol ratio was 4.3. MeanIMTwas 0.62 mm. All lipid markers were significantly correlated with IMT. This correlation was higher for non-HDL cholesterol (r = 0.24, p < 0.0001) and total/HDL cholesterol ratio(r = 0.23, p < 0.0001). In both men and women, total/HDL cholesterol ratio was the best predictor of having an IMT over the 75th percentile (odds ratio 1.21, 95% confidence intervals 1.09-1.35, p < 0.01). Conclusions: Total/HDL cholesterol ratio was the best determinant of subclinical atherosclerosis.