Purinas y ácido úrico en pre-eclampsia: interacciones fisiopatológicas y proyecciones en investigación

• Carlos Escudero ^[2] ; Patricio Bertoglia ^[3] ; Felipe Muñoz ^[3] ; James M Roberts ^[1]
  1. [1] University of Pittsburgh

     University of Pittsburgh

     City of Pittsburgh, Estados Unidos

     
  2. [2] Universidad del Bío Bío Departamento de Ciencias Básicas Grupo de Investigación en Angiogénesis Tumoral
  3. [3] Hospital Clínico Herminda Martin Servicio de Ginecología y Obstetricia

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• Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 141, Nº. 7, 2013, págs. 895-902
• Idioma: español
• Títulos paralelos:
  • Uric acid and purine plasma levels as plausible markers for placental dysfunction in pre-eclampsia
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• Resumen

  • Uric acid is the final metabolite of purine break down, such as ATP, ADP, AMP, adenosine, inosine and hypoxanthine. The metabolite has been used broadly as a renal failure marker, as well as a risk factor for maternal and neonatal morbidity during pre-eclamptic pregnancies. High purine levels are observed in pre-eclamptic pregnancies, but the sources of these purines are unknown. However, there is evidence that pre-eclampsia (mainly severe pre-eclampsia) is associated with an increased release of cellular fragments (or microparticles) from the placenta to the maternal circulation. These in fact could be the substrate for purine metabolism. Considering this background, we propose that purines and uric acid are part of the same physiopathological phenomenon in pre-eclampsia (i.e., placental dysfunction) and could become biomarkers for placental dysfunction and postnatal adverse events.