Impacto clínico de un sistema de farmacovigilancia activa realizado por un farmacéutico en el reporte y subnotificación de reacciones adversas a medicamentos

Ignacio Sánchez ^[1] ; Cristián Amador ^[2] ; José Cristian Plaza ^[3] ; Gonzalo Correa ^[1] ; Roberto Amador ^[1]
1. [1] Hospital del Salvador
  
  Hospital del Salvador
  
  Santiago, Chile
2. [2] Universidad de Chile
  
  Universidad de Chile
  
  Santiago, Chile
3. [3] Pontificia Universidad Católica de Chile
  
  Pontificia Universidad Católica de Chile
  
  Santiago, Chile
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Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 142, Nº. 8, 2014, págs. 998-1005
Idioma: español
Títulos paralelos:
- Assessment of an active pharmacovigilance system carried out by a pharmacist
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Resumen
- Background: Despite the importance of notifying and preventing adverse drug reactions (ADRs), they are under reported and their consequences are not adequately evaluated. Aim: To assess the impact of a pharmacovigilance system carried out by a pharmacist. Material and Methods: In an internal medicine service, the spontaneous report of ADRs was compared blindly with an active pharmacovigilance system in which a pharmacist detected, monitored and prevented ADRs. Results: A total of 1,196 patients was included. Of these 604 were hospitalized in intervened wards, where 50 suspected ADRs in 47 patients were reported. In non-intervened wards, only three ADRs were spontaneously reported. Therefore, the pharmacovigilance system significantly improved the detection and report of ADRs with a risk ratio of 15.4 (95% confidence intervals 4.8-49.1). Sixty six percent of ADRs were classified as severe. Antimicrobials were the main group of medications causing ADRs in 44% of reports. Forty three percent of ADRs were preventable and prolonged hospital stay by a mean of eight days. Conclusions: An active pharmacovigilance system carried out by pharmacists improves the detection of ADRs and promotes its prevention.