Frecuencia de anticuerpos para diagnóstico de enfermedad celíaca en pacientes con enfermedades del tejido conectivo y artropatías inflamatorias

• Graciela Rita Rodríguez ^[2] ; Federico Zazzetti ^[1] ; Silvia Raquel da Representaçao ^[3] ; María Verónica Lencina ^[4] ; Juan Carlos Barreira ^[1] ; Karina Elizabeth Álvarez ^[2]
  1. [1] Hospital Británico de Buenos Aires

     Hospital Británico de Buenos Aires

     Argentina

     
  2. [2] Hospital General de Agudos Dr. I. Pirovano Sección de Reumatología
  3. [3] Hospital General de Agudos Dr. I. Pirovano Unidad de Laboratorio Central
  4. [4] Instituto de Rehabilitación Psicofísica Sección de Reumatología

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• Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 142, Nº. 12, 2014, págs. 1510-1516
• Idioma: español
• Títulos paralelos:
  • Serum anti endomysial and anti transglutaminase antibodies in patients with connective tissue diseases
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• Resumen

  • Background: The detection of anti-transglutaminase IgA (tTG) and anti-endomysial (EMA) is used for screening of celiac disease (CD) with a sensitivity and specificity of 90 and 99% respectively. There is an association between CD and connective tissue diseases (CTD). Aim: To report the frequency of IgA tTG and EMA in patients with a definite diagnosis of CTD and inflammatory arthropathies (IA). Material and Methods: One hundred forty nine patients, aged 19 to 86 years (133 females) with CTD and IA were studied. tTG were determined by ELISA and EMA by indirect immunofluorescence. Results: Eight participants had at least one positive antibody (5.4%, confidence intervals (CI) = 1.8-9), six had both (4.0% CI = 0.9-7.2) and two had only tTG positive. An intestinal biopsy was performed in four of these participants, finding a marked villous atrophy in three and partial atrophy in one. Conclusions: Five percent of this group of patients with CTD or IA had positive antibodies for CD.