Encefalitis autoinmune por anticuerpos contra el receptor GABA-A: Caso clínico

• Pablo González R ^[1] ; Lorena Hudson A ^[1] ; Esteban Basáez M ^[1] ; Marcelo Miranda C ^[1]
  1. [1] Clínica Las Condes

     Clínica Las Condes

     Santiago, Chile

     
• Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 144, Nº. 11, 2016, págs. 1491-1493
• Idioma: español
• Títulos paralelos:
  • Autoimmune encephalitis induced by antibodies against GABA-A receptor
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• Resumen

  • Among autoimmune encephalitides, a prevalent group are those associated with antibodies against the N-Methyl-D-aspartate receptor, which present with behavior abnormalities, psychosis, seizures and abnormal movements. A new variant, mediated by antibodies against the GABA-A receptor, was recen­tly described. We report a 66-years-old female with this form of encephalitis whose main manifestation was the presence of severe seizures leading to status epilepticus. The patient had a good response to immunomodulatory therapy with intravenous methylprednisolone, azathioprine and anticonvulsants. The laboratory tests initially detected anti-thyroid peroxidase antibodies which lead to the misdiagnosis of Hashimoto Encephalitis, which was ruled out after the detection of antibodies against GABA-A receptor. No malignancy was detected.