Caracterización del metabolismo óseo mineral en pacientes con enfermedad renal crónica en hemodiálisis en el Servicio de Salud Metropolitano Sur, Santiago de Chile

• Andrea Ruiz de Arechavaleta ^[1] ; Nerio Quintero ^[4] ; Daniela Parra E.U ^[4] ; Aquiles Jara ^[2] ; Moisés Russo ^[3] ; Pedro Zitko ^[5] ; Jacqueline Pefaur ^[6]
  1. [1] Universidad de Chile

     Universidad de Chile

     Santiago, Chile

     
  2. [2] Pontificia Universidad Católica de Chile

     Pontificia Universidad Católica de Chile

     Santiago, Chile

     
  3. [3] Universidad Diego Portales

     Universidad Diego Portales

     Santiago, Chile

     
  4. [4] Hospital Barros Luco Trudeau Unidad de Hemodiálisis
  5. [5] Hospital Barros Luco Trudeau Unidad de Estudios Asistenciales
  6. [6] Hospital Barros Luco Trudeau Departamento de Nefrología

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• Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 143, Nº. 2, 2015, págs. 168-174
• Idioma: español
• Títulos paralelos:
  • Bone mineral metabolism in patients with chronic kidney disease on dialysis in Southern Metropolitan Santiago
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• Resumen

  • Background: Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) is a condition of dialysis patients associated with both morbidity and mortality. Management is based on clinical guidelines with goals that are hard to comply with. Aim: To describe and compare biochemical variables associated with this disorder in two different time periods. Material and Methods: Revision of medical records of 814 patients (49% females) dialyzed during 2009 and 1018 patients (48% females), dialyzed during 2012 in Southern Metropolitan Santiago. Information about serum calcium, phosphorus, parathyroid hormone (PTH) and albumin was retrieved. Results: Median PTH values in 2009 and 2012 were 222.5 and 353.5 pg/ml respectively (p < 0.05). The figures for serum calcium corrected by albumin were 9.0 and 8.5 mg/dl respectively (p < 0.05). The figures for phosphorus were 4.7 and 5.0 mg/dl respectively (p < 0.05). The Calcium x Phosphorus product was 41.4 and 42.5 mg²/dl² (p < 0.05). Of note, the proportion patients with serum calcium below recommended levels (< 8.4 mg/dl) increased from 16% to 40% from 2009 to 2012. The proportion of patients with biochemical variables within recommended ranges was lower in 2012 than in 2009. Conclusions: There was a low proportion of patients with bone metabolism parameters within ranges recommended by clinical guidelines. These parameters were worst in 2012.