Trombolisis intravenosa en accidente cerebro vascular isquémico agudo en un hospital público de Chile: Análisis prospectivo de 54 casos

Carlos Guevara O; Kateryna Bulatova; Felipe Aravena; Sheila Caba; Juan Monsalve; Hugo Lara; Elena Nieto; Isabel Navarrete; Marcelo Morales

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Trombolisis intravenosa en accidente cerebro vascular isquémico agudo en un hospital público de Chile: Análisis prospectivo de 54 casos

Carlos Guevara O ^[1] ; Kateryna Bulatova ^[1] ; Felipe Aravena ^[1] ; Sheila Caba ^[2] ; Juan Monsalve ^[2] ; Hugo Lara ^[2] ; Elena Nieto ^[2] ; Isabel Navarrete ^[2] ; Marcelo Morales ^[2]
1. [1] Universidad de Chile
  
  Universidad de Chile
  
  Santiago, Chile
2. [2] Hospital San Juan de Dios
  
  Hospital San Juan de Dios
  
  Santiago, Chile
Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 144, Nº. 4, 2016, págs. 442-450
Idioma: español
Títulos paralelos:
- Intravenous thrombolysis for ischemic stroke: Experience in 54 patients
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Resumen
- Background: Intravenous thrombolysis with recombinant tissue plasminogen activator (rt-PA) reduces disability in patients with ischemic stroke. However, its implementation in Chilean public general hospitals has been slow and faces some difficulties. Aim: To analyze the results of an intravenous thrombolysis protocol implementation in a public general hospital. Material and Methods: During a lapse of 28 months a standardized protocol for intravenous thrombolysis implemented in the emergency room of a public hospital, was prospectively evaluated. Fifty four patients with ischemic stroke were treated and assessed three months later as outpatients. Results: At three months of follow-up, 66.4% of patients subjected to thrombolysis had a favorable evolution, defined as having 0 to 1 points in the modified Rankin scale. Intracerebral hemorrhage rate was 11.1%, including 5.5% of symptomatic intracerebral hemorrhage. Four percent of patients had systemic bleeding complications after thrombolysis. The mortality rate was 14.8%. Conclusions: The success rates, mortality, and complications rate were comparable to the results obtained in international studies, despite of the absence of a stroke unit to manage stroke and its complications.