Adenovirus 36 y su potencial contribución en el desarrollo de obesidad
- Autores: Francisca Villavicencio, Macarena Valladares Vega
- Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 145, Nº. 8, 2017, págs. 1054-1059
- Idioma: español
- Títulos paralelos:
- The potential contribution of adenovirus 36 to the development of obesity
- Enlaces
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Resumen
The evidence of the last 20 years shows a link between viral infections and obesity in animals and humans. There are five adenovirus which have been associated with development of obesity in animals. SMAM-1 virus was the first studied in humans associated with obesity. There is compelling evidence that Ad-36 virus could contribute to the development of obesity in humans and it is related with body mass index (BMI). This manuscript reviews the association between Ad-36 and the other four virus infections with obesity. An electronic search of articles in the databases PubMed and Scielo, with use of key words: obesity, infection, adipose tissue, Ad-36, 3T3-L1 was performed. The search was restricted “human” and “animals”. The importance of the relationship between virus infections and obesity has increased over the past two decades. Ad-36 shows more compelling evidence in humans. There are reports involving this virus in the enhancement of adipogenesis, adipocyte differentiation, a lower secretion of leptin and an increased insulin sensitivity. Future work should focus in larger cohort studies to confirm this association, which explains the global obesity epidemic from a new perspective.
