Chemical basis for the antimicrobial activity of acetanilides

• Hector R. Bravo ^[1] ; Boris Weiss-López ^[1] ; Madeleine Lamborot ^[1] ; Sylvia Copaja ^[1]
  1. [1] Universidad de Chile

     Universidad de Chile

     Santiago, Chile

     
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 48, Nº. 4, 2003, págs. 27-30
• Idioma: inglés
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• Resumen

  • In vitro antimicrobial activity of a series of substituted acetanilides against S. aureus, E. coli and C. albicans were measured at two concentrations, 250 mug/ml and 500 mug/ml. Only the structures substituted with halogens in Calpha and electron acceptors in the aromatic ring are bioactive. The results are rationalized in terms of the acid properties of the N-H bond, as calculated using AM1-MO theory