Synthesis and resolution of the optical isomers of thiencynonate hydrochloride

• HE LIU ^[1] ; LI-PING LIU ^[1] ; JING-LI WANG ^[1] ; BO-HUA ZHONG ^[1] ; KE-LIANG LIU ^[1]
  1. [1] Beijing Institute of Pharmacology and Toxicology
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 51, Nº. 3, 2006, págs. 961-963
• Idioma: inglés
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• Resumen

  • Thiencynonate hydrochloride (N-methyL-9á-(3-azabicyclo[3,3,1]nonanyl)-2'-cyclopentyL-2'- hydroxyL-2'-thienylacetate, I·HCl), an new muscarinic receptor antagonist, was synthesized and its enantiomers were obtained form the optical pure of demethylation product II. A convenient resolution method of demethylation product II has been developed with N-p- toluenesulfonylglutamic acid as the resolution reagent. The structures of I and II were elucidated by X-ray analysis