Regioselective synthesis and antimicrobial activity of o-alkylated physcion'S derivatives

• N MANOJLOVIC ^[1] ; Z MARKOVIC ^[1] ; M DURIC ^[1]
  1. [1] University of Kragujevac

     University of Kragujevac

     Opština Kragujevac, Serbia

     
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 52, Nº. 4, 2007, págs. 1330-1331
• Idioma: inglés
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• Resumen

  • Regioselectivity in the reaction of microwave promoted O-alkylation of physcion in the presence of montmorillonite clay K-10 was discussed. The mechanism of formation of corresponding anions of physcion was investigated using semiempirical molecular-orbital methods. The results of antibacterial and antifungal activity of the obtained derivatives showed that the introduction of different substituents (OCF£3, OCH2C(CH3)=CH2, OCH2CH2CH3 and OCH2C6H5), at the C-1 and C-8 atoms led to a remarkable change in their antimicrobial activity