Synthesis of novel pyrazole, coumarin and pyridazine derivatives evaluated as potential antimicrobial and antifungal agents

• WAGNAT W WARDAKHAN ^[1] ; NADIA A LOUCA ^[2]
  1. [1] National Organization for Drug Control & Research (NODCAR)
  2. [2] Hormones Department, National Research Center
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 52, Nº. 2, 2007, págs. 1145-1149
• Idioma: inglés
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• Resumen

  • The reaction of cyanoacetylhydrazine with ω-bromoacetophenone gave the N’-[2-bromo-1-phenylethylidene]-2-isocyanoacetohydrazide (3). The latter compound underwent ready cyclization when treated with potassium cyanide to give the 1-(isocyanoacetyl)-3-phenyl-1H-pyrazol-5-amine (6). Compound 6 underwent a series of heterocyclization to give either coumarin, pyridazine, 1,2,4-triazine or thiophene derivatives. The antimicrobial and antifungal activities of the newly synthesized products were measured, using two Gram-negative (Escherichia coli and Pseudomonas aeruginosa), two Gram-positive bacteria (Bacillus subtilis and Bacillus cereus) and the antifungal activity using Candida albicans