In vitro trypanocidal activity and chemical constituents of aspilia platyphylla (baker) blake

• RODRIGO C. S. VENEZIANI ^[1] ; DIONÉIA C. R. DE OLIVEIRA ^[3] ; SÉRGIO ALBUQUERQUE ^[2] ; WILSON R. CUNHA ^[1]
  1. [1] Universidade de Franca

     Universidade de Franca

     Brasil

     
  2. [2] Universidade de São Paulo

     Universidade de São Paulo

     Brasil

     
  3. [3] USP Faculdade de Ciências Farmacêuticas de Ribeirão Preto Departamento de Física e Química

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• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 52, Nº. 1, 2007, págs. 1092-1094
• Idioma: inglés
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  • Chloroform and ethanol crude extracts of the underground parts of Aspilia platyphylla (Baker) Blake (Asteraceae - Heliantheae) were submitted to phytochemical investigations and trypanocidal assay. Both extracts were subjected to a partition process with organic solvents. Using a GC analysis method, it was possible to identify the tritepernes β-amyrin, α-amyrin, β-friedelanol, and friedelin, as well as the phytosterol stigmasterol, directly in the n-hexane soluble fraction obtained from the CHCl3 crude extract. Through chromatographic methods and spectroscopic techniques, it was possible to isolate and identify ent-pimara-8(14), 15-dien-19-oic acid; 7-keto-ent-pimara-8(14),15-dien-19-oic acid; 6-acethyl-8-hydroxy-2,2-dimethylchromene; 7β-hydroxy-ent-pimara-8(14),15-dien-19-oic acid; ethyl 6,7-dihydroxycinammate, and rutin in the CH2Cl2 and AcOEt soluble fractions obtained from the CHCl3 and EtOH crude extracts. The CH2Cl2 soluble fractions obtained from the CHCl3 and EtOH crude extracts are active in vitro against the trypomastigote forms of Trypanossoma cruzi (Y strain)