Synthesis, characterization and superoxide dismutase actwity of the manganese(ii) mixed ligand complexes containing sulfathiazole

J.R ANACONA ^[1] ; JESUS DIAZ ^[1]
1. [1] Universidad de Oriente
  
  Universidad de Oriente
  
  Venezuela
Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 53, Nº. 4, 2008, págs. 1702-1704
Idioma: inglés
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Resumen
- Manganese(II) metal ion and sulfathiazole (Hstz) react with pyrrolidine (pyrro), piperidine (pipe) and ethylenediamine (en) to form the following mixed ligand complexes : [Mn(stz)2(pyrro)2], [Mn(stz)2(pipe)2] and [Mn(stz)2(en)2] which were characterized by physicochemical and spectroscopic methods. Their spectra indicated that the sulfathiazole is probably acting as amonoanionic unidentate chelating agent. The superoxide dismutase mimetic activity of the complexes was investigated using the indirect xanthine-xanthine oxidase-nitroblue tetrazolium method and compared to that of the native enzyme.