Circular RNAs: characteristics, functions, mechanisms, and potential applications in thyroid cancer
-
Mengmeng Wu [1] ; Haibin Yuan [1] ; Weiwei Zou [1] ; Shujian Xu [1] ; Song Liu [1] ; Qiang Gao [1] ; Qingqun Guo [1] ; Yong Han [1] ; Xingguo An [1]
-
[1] Binzhou Medical University
Binzhou Medical University
China
-
- Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 26, Nº. 4, 2024, págs. 808-824
- Idioma: inglés
- Texto completo no disponible (Saber más ...)
-
Resumen
Thyroid cancer (TC) is one of the most common endocrine malignancies, and its incidence has increased globally. Despite extensive research, the underlying molecular mechanisms of TC remain partially understood, warranting continued exploration of molecular markers for diagnostic and prognostic applications. Circular RNAs (circRNAs) have recently garnered significant attention owing to their distinct roles in cancers. This review article introduced the classification and biological functions of circRNAs and summarized their potential as diagnostic and prognostic markers in TC. Further, the interplay of circRNAs with PI3K/Akt/mTOR, Wnt/β-catenin, MAPK/ERK, Notch, JAK/STAT, and AMPK pathways is elaborated upon. The article culminates with an examination of circRNA's role in drug resistance of TC and highlights the challenges in circRNA research in TC.
