Synthesis and microbiological evaluation of mannich bases derived from 4,6-diacetylresorcinol

• ASIF HUSAIN ^[1] ; MOHAMMAD MAAZ ^[1] ; KHURSHEED AHMAD ANSARI ^[1] ; AUSAF AHMAD ^[2] ; MOHD RASHID ^[1]
  1. [1] Hamdard University

     Hamdard University

     Pakistán

     
  2. [2] University of Rochester Medical Center

     University of Rochester Medical Center

     City of Rochester, Estados Unidos

     
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 55, Nº. 3, 2010, págs. 332-334
• Idioma: inglés
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• Resumen

  • In the present investigations 4,6-diacetyl resorcinol 1 on condensation with formaldehyde and some selected amines following the Mannich reaction conditions yielded eight new Mannich bases 2a-h. It was observed that the reaction did not take place at the acetyl function but occurred at the 2-position into the aromatic ring. The compounds were characterized on the basis of elemental analysis as well as ¹H NMR and Mass spectral data. The antibacterial and antifungal activities of the title compounds were tested by the disc diffusion method using nutrient agar medium against various microorganisms such as gram positive Staphylococcus aureus and Bacillus subtilis, gram negative Escherichia coli and the fungi Aspergillus flavus and Candida albicans. Ofloxacin and voriconazole at 20 ug/mL were used as standard drugs for antibacterial and antifungal activities, respectively.