Synthetic, spectral, antimicrobial and qsar studies on novel mannich bases of glutarimides

• ANJU DAS MANIKPURI ^[1] ; SHEELA JOSHI ^[2] ; PADMAKAR V KHADIKAR ^[3]
  1. [1] ISLEJPS Academy Department of chemistry
  2. [2] Devi Ahilya University Takshashila Campus School of Chemical Sciences
  3. [3] Laxmi fumigation andpest control centre Research Division

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• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 55, Nº. 3, 2010, págs. 283-292
• Idioma: inglés
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  • A series of forty Mannich bases of glutarimides with sulfonamides and secondary amines were synthesized and evaluated in vitro against six pathogenic Gram-positive and Gram-negative bacteria. The synthesized Mannich bases were characterized by elemental and spectral analysis. The modeling anti-bacterial activities of these newly synthesized Mannich bases against six bacteria was attempted employing ¹H NMR chemical shift, physicochemical properties and topological indices as the correlating parameters. Our results, based on Quantitative Structure-Activity Relationships (QSARs), have indicated that statistically significant models are obtained for modeling the anti-bacterial activities The results are discussed critically using a variety of statistical parameters.