Preparation and characterization of the emamectin benzoate/hydroxypropyl-b-cyclodextrin inclusion complex

• PABLO TORRES ^[1] ; FRANCISCO VILLA ; JAVIER GONZÁLEZ ^[2] ; JOSÉ TRONCOSO ^[2] ; CARLOS VONPLESSING ^[1]
  1. [1] Universidad of Concepción Faculty of Pharmacy Department of Pharmacy
  2. [2] Ewos Innovation
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 56, Nº. 4, 2011, págs. 951-954
• Idioma: inglés
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• Resumen

  • The objective of this study was to prepare an inclusion complex of the insecticide emamectin benzoate (EB) with hydroxypropyl-β-cyclodextrin (HO-β-CD) by co-evaporation and spray drying methods. The complexation of both compounds was evaluated on the aqueous and solid state using phase solubility diagrams, differential scanning calorimetry (DSC), X-Ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The aqueous solubility of the inclusion complexes at pH 8 had a 2-fold increase respect to the drug alone and dissolution profiles showed a rise in the dissolution rate. These results suggest that the use of HO-β-CD could be an interesting alternative to enhance the bioavailability of EB in salmons.