New amides of sulphonamides: Synthesis and biological evaluation

• ASIF HUSAIN ^[1] ; AUSAF AHMAD ^[2] ; M MUJEEB ^[1] ; MYMOONA AKHTER ^[1]
  1. [1] Hamdard University

     Hamdard University

     Pakistán

     
  2. [2] University of Rochester Medical Center

     University of Rochester Medical Center

     City of Rochester, Estados Unidos

     
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 55, Nº. 1, 2010, págs. 74-77
• Idioma: inglés
• Enlaces
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• Resumen

  • A series of amide-derivatives has been synthesized by establishing an amide linkage (-CONH-) between appropriate sulphonamide moiety and different 3-(4-substituted-benzoyl) propionic acids through one-pot reaction. The structures of the newly synthesized compounds were established on the basis of modern analytical techniques. These amides were evaluated for their antiinflammatory, ulcerogenic and antibacterial activities. Some of the compounds showed good antiinflammatory activity. Additionally, these derivatives were very low in their ulcerogenic action.