Esr, electrochemical and orac studies of nitro compounds with potential antiprotozoal actvity

• MARÍA ARAVENA C ^[1] ; ROBERTO FIGUEROA ^[1] ; CLAUDIO OLEA-AZAR ^[1] ; VICENTE J ARÁN ^[2]
  1. [1] Universidad de Chile

     Universidad de Chile

     Santiago, Chile

     
  2. [2] Consejo Superior de Investigaciones Científicas

     Consejo Superior de Investigaciones Científicas

     Madrid, España

     
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 55, Nº. 2, 2010, págs. 244-249
• Idioma: inglés
• Enlaces
  • Texto completo
• Resumen

  • Cyclic Voltammetry (CV) and electrón spin resonance (ESR) techniques were used in the investigation of several potentially antiprotozoal nitro derivatives of dihydroquinoxaline and indazole. A self-protonation process involving protonation of the nitro group due to the presence of an acidic protón in the structure of the nitro compound was observed in the first step of an ECErev reduction mechanism. ESR spectra of the free radicals obtained by electrochemical reduction in situ were characterized and analyzed. The ESR spectra showed three different hyperfine patterns for both families of compounds. In order to evaluate the free radical scavenger properties of these nitrocompounds we carried out ORAC-Fl (Oxygen Radical Antioxidant Capacity) assay. These derivatives showed a low antioxidant capacity.