Formulation and characterization of inclusion complexes using hydroxypropyl-β-cyclodextrin and florfenicol with chitosan microparticles

• CRISTIAN ROGEL ^[1] ; NÉSTOR MENDOZA ^[1] ; JOSÉ TRONCOSO ^[2] ; JAVIER GONZÁLEZ ^[2] ; CARLOS VON PLESSING ^[1]
  1. [1] Universidad de Concepción

     Universidad de Concepción

     Comuna de Concepción, Chile

     
  2. [2] Ewos Innovation
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 56, Nº. 1, 2011, págs. 574-578
• Idioma: inglés
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• Resumen

  • The interaction between Florfenicol (FF), Hydroxypropyl-β-cyclodextrin (HPβCD), and Chitosan (CH) has been studied in aqueous solution and in solid state, using 3 preparation methods (Evaporation, Lyophilization, Spray Drying) for HPβCD and only Spray Drying for Chitosan. The phase solubility study shows that the complex is formed with 1:1 stoichiometry and 181,4 M¹ as the association constant. The analysis with Differential Scanning Calorimetry (DSC) together with Scanning Electron Microscopy (SEM) micrographs evidenced the formation of inclusion complexes, mainly with the product prepared by spray drying. Studies in vitro showed that FF solubility was improved almost to double, with a better dissolution profile exhibited by the product prepared by spray drying.