Synthesis of some novel and biologically active schiff bases bearing a 1,3,4-thiadiazole moiety under acidic and ptc conditions

• A MOBINIKHALEDI ^[1] ; M JABBARPOUR ^[1] ; A HAMTA ^[1]
  1. [1] Arak University

     Arak University

     Irán

     
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 56, Nº. 3, 2011, págs. 812-814
• Idioma: inglés
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• Resumen

  • The synthesis of some new Schiff bases bearing a 1,3,4-thiadiazole moiety, 3a-l, by reaction of 2-amino-5-mercapto-1,3,4-thiadiazole with aromatic aldehydes under acidic and phase transfer catalyst (PTC) conditions was studied. The structure of all the Schiff bases was characterized using FT-IR and NMR spectroscopy, and elemental analyses. The antibacterial activity of these compounds was investigated against Staphylococcus aureus (RTCC, 1885), and Escherichia coli (ATCC, 35922).