Synthesis and antitubercular activity of pyridazinone derivatives

• ASIF HUSAIN ^[1] ; AFTAB AHMAD ^[2] ; ANIL BHANDARI ^[2] ; VEERMA RAM ^[2]
  1. [1] Hamdard University

     Hamdard University

     Pakistán

     
  2. [2] National University

     National University

     Estados Unidos

     
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 56, Nº. 3, 2011, págs. 778-780
• Idioma: inglés
• Enlaces
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• Resumen

  • Two series of pyridazinone derivatives (19-34) were synthesized and evaluated for antitubercular activities against Mycobacterium tuberculosis H37Rv strain. The results illustrated that among the synthesized compounds, compound 25, 5-(4-hydroxy-3-methoxybenzyl)-3-(4-chloro-phenyl)-1,6-dihydro-6-pyridazinone emerged as a lead compound with good antitubercular activity. Four more compounds, (21, 22, 29 & 33) were significant in their antitubercular action.