Simultaneous determination of ambroxol, guaiphenesin and levosalbutamol sulphate in pharmaceutical formulations with the use of four rapid derivative spectrophotometric methods

• Autores: Gagandeep Gagandeep, Navdeep Kaur Gill, Karan Karan, G S Sarma, Arti Thakkar
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 57, Nº. 4, 2012, págs. 1436-1441
• Idioma: inglés
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• Resumen

  • Four simple, rapid, accurate, precise, reliable and economical spectrophotometric methods have been proposed for simultaneous determination of ambroxol, guaiphenesin and levosalbutamol sulphate, in pure and pharmaceutical formulations without any prior separation or purification step. The methods are first derivative zero crossing spectrophotometry, simultaneous equation, derivative ratio spectra zero crossing and double divisor ratio spectra derivative method. Developed methods show best results in terms of linearity, accuracy, precision, LOD and LOQ for standard laboratory mixtures of pure drugs and marketed formulations. Common excipients and additives did not interfere in determinations of these APIs. Results obtained by the proposed methods have been statistically compared by means of student t-test.