Synthesis, x-ray crystallography, molecular docking and biological screening of 2-aminophenol based schiff bases

• MUHAMMAD ASLAM ^[5] ; ITRAT ANIS ^[1] ; NIGHAT AFZA ^[5] ; MUHAMMAD TAHIR HUSSAIN ^[2] ; RASHAD MEHMOOD ^[3] ; AJAZ HUSSAIN ^[6] ; SAMMER YOUSUF ^[1] ; LUBNA IQBAL ^[5] ; SAMINA IQBAL ^[5] ; INAMULLAH KHAN ^[4]
  1. [1] University of Karachi

     University of Karachi

     Pakistán

     
  2. [2] National Textile University

     National Textile University

     Pakistán

     
  3. [3] Hazara University

     Hazara University

     Pakistán

     
  4. [4] University of Peshawar

     University of Peshawar

     Pakistán

     
  5. [5] Pakistan Council of Scientific and Industrial Research Laboratories Complex
  6. [6] Government College University Department of Chemistry

  Mostrar afiliaciones +
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 58, Nº. 3, 2013, págs. 1867-1871
• Idioma: inglés
• Enlaces
  • Texto completo
• Resumen

  • Schiff bases, 2-{[(2-hydroxyphenyl)methylidene]amino}phenol (4) and 2-{[3-4-(dimethylamino)phenyl-2-propenylidene]amino}phenol (5), have been synthesized by the condensation of 2-aminophenol (1) with 2-hydroxybenzaldehyde (2) and 4-dimethylaminocinnamaldehyde (3), respectively. They showed good lipoxygenase inhibition and antioxidant activities, as compound 4 showed potent antioxidant activity. The products also showed good activities against Gram-positive: S. intermedius, B. subtilis and S. aureus, and Gram-negative: E. coli and S. typhi bacteria, as compounds 5 and 4 are excellent active against B. subtilis and S. typhi, respectively. These good to potent activities may be due to the presence of free hydroxyl and amino groups. They showed non-significant urease inhibition activity.