Preliminary antiproliferative evaluation of natural,-synthetic benzaldehydes and benzyl alcohols

• ALEJANDRO MADRID ^[3] ; LUIS ESPINOZA ^[3] ; KAREN CATALÁN ^[3] ; CESAR GONZALEZ ^[3] ; IVÁN MONTENEGRO ^[3] ; MARCO MELLADO ^[3] ; ENRIQUE WERNER ^[1] ; MAURICIO CUELLAR ^[2] ; JOAN VILLENA ^[2]
  1. [1] Universidad del Bío-Bío

     Universidad del Bío-Bío

     Comuna de Concepción, Chile

     
  2. [2] Universidad de Valparaíso

     Universidad de Valparaíso

     Valparaíso, Chile

     
  3. [3] Universidad Técnica Federico Santa María Departamento de Química

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• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 58, Nº. 3, 2013, págs. 1814-1816
• Idioma: inglés
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  • Vanillin, o-vanillin, natural and synthetic benzaldehydes and benzyl alcohols were assessed for antiproliferative effects using different human cell lines. Benzyl alcohols were synthesized from benzaldehydes reduced with NaBH4 in methanol solution. A new method for deprotection of ether compounds with TiCl4 solution was achieved with better performance, than previously reported. Twenty four compounds were tested. The in vitro growth inhibition assay was based on sulphorhodamine dye to quantify cell viability. Catechol 9 derived from piperonal as well as compounds 4 and 12 showed higher cytotoxicity on breast and prostate cancer cell lines (MDA-MB-231 and PC-3 respectively). o-Vanillin 5 has the highest cytotoxicity for all cell lines. IC50 values of 35.40 ± 4.2 μM Breast MDA-MB231; 47.10 ± 3.8 μM Prostate PC-3; 72.50 + 5.4 μM Prostate DU-145; 85.10 + 6.5 μM and Colon HT-29, were obtained without toxicity towards dermal human fibroblast (DHF cells).