Development of n-phenyl-3-pyridin-2-yl imino derivatives as anticoagulants potential factor viia inhibitors

• PRAFULLA B CHOUDHARI ^[1] ; MANISH S BHATIA ^[1]
  1. [1] Bharati Vidyapeeth College of pharmacy Kolhapur Drug development sciences research group
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 58, Nº. 2, 2013, págs. 1667-1673
• Idioma: inglés
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• Resumen

  • The ability of the body to maintain the flow of blood following vascular injury is an important process for the survival. Normally the process of blood clotting and then the subsequent dissolution of the clot, following repair of the injured tissue, is known as hemostasis. Anticoagulants are widely utilized in the treatment of all type of thromboembolism. The present communication deals with the design and docking studies of a series of N-Phenyl-3-Pyridin-2-yl imino analogs and their screening anticoagulants and virtually confirming the mechanism of action as factor VIIa Inhibitors. The compounds were synthesized in excellent yields (70-80%) and the structures were established on the basis of consistent IR, 1H NMR, Mass spectroscopy and elemental analysis. All the synthesized compounds were found to exhibit profound anti coagulant activity.