Inhibition of quorum sensing by drimane lactones from chilean flora

• GERARDO CÁRCAMO ^[1] ; MARIO SILVA ^[1] ; JOSÉ BECERRA ^[1] ; HOMERO URRUTIA ^[1] ; KATHERINE SOSSA ^[1] ; CRISTIAN PAZ ^[2]
  1. [1] Universidad de Concepción

     Universidad de Concepción

     Comuna de Concepción, Chile

     
  2. [2] Universidad de La Frontera

     Universidad de La Frontera

     Temuco, Chile

     
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 59, Nº. 3, 2014, págs. 2622-2624
• Idioma: inglés
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• Resumen

  • Fifteen native Chilean plants were evaluated against the quorum sensing (QS) biosensor AI-1, Chromobacterium violaceum ATCC 12472. Three extracts showed inhibitory activity of QS: Drymis winteri J.R, Psoralea glandulosa L and Peumus boldus. Purification of secondary metabolites from barks of Drimys winteri showed that drimane sesquiterpenes were the main compounds in the tree. Polygodial, drimenol, isodrimeninol, drimenin, isodrimenin, cinnamolide and valdiviolide were isolated and evaluated in QS inhibition assays. Two α,β unsaturated lactones, cinnamolide and valdiviolide, with the carbonyl on position 12 of the drimane skeleton were found to be inhibitors of QS; other drimane lactones were not active.