Synthesis, molecular structures, and antimicrobial activities of n'-(3,5-dibromo-2-hydroxybenzylidene)-2-fluorobenzohydrazide and 7v'-(4-diethylamino-2-hydroxybenzylidene)-2-fluorobenzohydrazide

• YUN-XIAO FENG ^[1] ; LING-WEI XUE ^[1] ; CAI-XIA ZHANG ^[2]
  1. [1] Pingdingshan University College of Chemistry and Chemical Engineering
  2. [2] Shenhua Ningxia Coal Group Coal Chemical Industry Branch
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 59, Nº. 3, 2014, págs. 2555-2558
• Idioma: inglés
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• Resumen

  • Two new carbohydrazone derivatives, N'-(3,5-dibromo-2-hydroxybenzylidene)-2-fluorobenzohydrazide (1), and N'-(4-diethylamino-2-hydroxybenzylidene)-2-fluorobenzohydrazide (2), were prepared by the reaction of 2-fluorobenzohydrazide with 3,5-dibromo-2-hydroxybenzaldehyde and 4-diethylamino-2-hydroxybenzaldehyde, respectively. The compounds were characterized by elemental analyses, infrared spectra, and single crystal X-ray diffraction. The crystal of 1 crystallizes in monoclinic space group C2/c, with unit cell dimensions a = 36.0853(5) Å, b = 10.1711(2) Å, c = 17.3627(5) Å, β = 109.973(2)°, V = 5989.3(2) ų, Z = 16, R1 = 0.0544, wR2 = 0.1300. The crystal of 2 crystallizes in monoclinic space group P2l/c, with unit cell dimensions a = 10.6827(2) Å, b = 16.5256(3) Å, c = 9.8174(1) Å, β = 102.564(2)°, V = 1691.64(5) ų, Z = 4, R1 = 0.0772, wR2 = 0.2156. The compounds were assayed for antibacterial (Bacillus subtilis, Escherichia coli, Pseudomonas fluorescence and Staphylococcus aureus) and antifungal (Aspergillus niger and Candida albicans) activities by MTT method.