Prevalencia del anticuerpo anti receptor de fosfolipasa A2 sérico e histológico en pacientes con nefropatía membranosa en un Centro Universitario

• Autores: Alondra Frías, Paula Segura Hidalgo, Luis Toro Cabrera, Leticia Elgueta, Rubén Torres Díaz, Miriam Alvo
• Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 149, Nº. 1, 2021, págs. 7-12
• Idioma: español
• Títulos paralelos:
  • Phospholipase A2 receptor antigen antibodies in serum and renal biopsies of patients with membranous nephropathy
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• Resumen

  • Background: The discovery of the phospholipase A2 receptor antigen and its highly specific autoantibody (anti-PLA2R Ab) was useful for the diagnosis and follow-up of patients with membranous nephropathy (MN). Thus, some international guidelines recommend not performing renal biopsy in patients with positive serum anti-PLA2R Ab. Aim: To evaluate the prevalence of anti-PLA2R Ab in serum and renal tissue samples from Chilean patients with primary MN. Material and Methods: Twenty-eight patients aged 50 ± 14 years (20 males) with biopsy-proven primary MN plus a negative workup for secondary causes were included. Measurements of serum and renal histologic anti-PLA2R Ab were performed. The relationship between the findings of serum and tissue anti-PLA2R Ab was evaluated. Results: Fifteen patients (54 %) had anti-PLA2R Ab presence in serum and 19 patients (68%) had positive anti-PLA2R Ab in the renal biopsy. All patients with positive serum anti-PLA2R Ab had positive antibodies on immunohistochemistry. Conclusions: Serum anti-PLA2R Ab is potentially useful in the diagnosis of patients with suspected primary MN in Chilean population.