Antibacterial and enzyme inhibition screening of some new acetamide and azomethine derivatives

• SHAHID RASOOL ^[1] ; AZIZ-UR-REHMAN ^[1] ; MUHAMMAD ATHAR ABBASI ^[1] ; SABAHAT ZAHRA SIDDIQUI ^[1] ; SYED ADNAN ALI SHAH ^[2] ; IRSHAD AHMAD ^[3] ; SAIRA AFZAL ^[3]
  1. [1] Government College University Department of Chemistry
  2. [2] Universiti Teknologi Mara Catta-ur-Rahman Institute for Natural Products Discovery
  3. [3] The Islamia University of Bahawalpur Department of Pharmacy

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• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 60, Nº. 4, 2015, págs. 2704-2710
• Idioma: inglés
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  • The synthesis of poly-functional moieties as one unit has been under consideration by the synthetic chemists to search out new potent molecules. 2-Chlorobenzoic acid (1) was converted to 5-(2-chlorophenyl)-1,3,4-Oxadiazol-2-thiol (4) through a series of steps. This nucleophile was attached with different electrophiles, prepared by the reaction of aryl/alkyl amines with 2-bromoacetylbromide, in NaH/DMF to synthesize N-substituted-2-((5-(2-chlorophenyl)-1,3,4-Oxadiazol-2-yl)sulfanyl)acetamide, 7a-f. The molecule 4 was stepped to ethyl ester and carbohydrazide. The carbohydrazide was made to react with aryl carboxaldehydes in methanol to synthesize N'-substituted-2-(5-(2-chlorophenyl)-1,3,4-Oxadiazol-2-ylthio)acetohydrazide, 11a-i. The structures of all the molecules were corroborated through IR, ¹H-NMR and EI-MS spectral data. Both the series were screened for antibacterial and enzyme inhibition activity.