Rapid method of friedel-crafts alkylation of phloroglucinol by microwave in dry media and reusable catalyst

• ALEJANDRA P VERGARA ^[1] ; JAVIER A CONTRERAS ^[2] ; MAURICIO E OSORIO ^[2] ; MARCELA A CARVAJAL ^[1]
  1. [1] Centro de Biotecnología DAL
  2. [2] Universidad Técnica Federico Santa María Departamento de Química Laboratorio de Productos Naturales
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 60, Nº. 3, 2015, págs. 3069-3073
• Idioma: inglés
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• Resumen

  • A new rapid and efficient method for the synthesis of a series of alkylated phloroglucinols using conventional microwave is reported 4 phloroglucinol derivatives (4, 5, 6 and 7) were synthesized with good yields (~50%) by a Friedel-Crafts reaction through an Electrophilic Aromatic Substitution mechanism between geraniol/prenol and phloroglucinol, using reusable SiO2 and AgNO3 as the best catalyst tested without solvents under microwave irradiation.