Application of sba-15 functionalized sulfonic acid (sba-pr-so3h) as an efficient nanoreactor in the one-pot synthesis of pyrido[2,3-d]pyrimidine

• GHODSI MOHAMMADI ZIARANI ^[1] ; PARISA GHOLAMZADEH ^[1] ; ALIREZA BADIEI ^[2] ; SHIMA ASADI ^[1] ; ALI ABOLHASANI SOORKI ^[3]
  1. [1] Alzahra University Department of Chemistry
  2. [2] University of Tehran College of Science School of Chemistry
  3. [3] Shahid Beheshti University Academic Center of Education, Culture & Research Research Institute of Petroleum

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• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 60, Nº. 2, 2015, págs. 2975-2978
• Idioma: inglés
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  • Sulfonic acid functionalized nanoporous silica (SBA-Pr-SO3H) with a pore size of 6 nm was synthesized using surface modification of Santa Barbara Amorphous (SBA-15). It is a solid acid hexagonally nano-reactor with high surface area and is reusable, high selective, non-corrosiveness which can easily isolate from the products. An efficient and green one-pot three component reaction was developed for the synthesis of pyrido[2,3-d]pyrimidine derivatives via a simple, mild and effective solvent free reaction of 4(6)-aminouracil, barbituric acid and aromatic aldehydes in the presence using SBA-Pr-SO3H. In this reaction, SBA-Pr-SO3H was an effective nano-catalyst which gave the products in good to high yields in a shorter reaction time compared to the other published reports. Some of the products were strong antibiotics against Bacillus subtilis and Staphylococcus aureus.