Synthesis and antioxidant evaluation of novel phenothiazine linked substitutedbenzylideneamino-1,2,4-triazole derivatives

• SURESH MADDILA ^[1] ; MEHBUB MOMIN ^[1] ; SRIDEVI GORLE ^[2] ; LAVANYA PALAKONDU ^[3] ; SREEKANTH B JONNALAGADDA ^[1]
  1. [1] University of KwaZulu-Natal School of Chemistry & Physics
  2. [2] University of KwaZulu-Natal School of Life Sciences Discipline of Biochemistry
  3. [3] Annamacharya Institute of Technology & Sciences J.N.T. University Department of Chemistry

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• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 60, Nº. 2, 2015, págs. 2919-2923
• Idioma: inglés
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  • A series of novel 5-((10H-phenothiazin-10yl)methyl)-4-(substitutedbenzylideneamino)-4H-1,2,4-triazole-3-thiol derivatives (6a-i) have been synthesized from compound (1) through a multi-step reaction. The key intermediate (5) afforded a series of title compounds (6a-i) on condensation with various suitable aldehydes in the presence of H2SO4. The structures of novel compounds were characterized based on their elemental analysis, IR, ¹H-NMR, 13C-NMR and MS spectral data. All these novel compounds were screened for their in vitro antioxidant activity by employing nitric oxide, hydrogen peroxide, and DPPH radical scavenging assays. The compounds 6d, 6e and 6i demonstrated potent antioxidant activity as these contain the electron-releasing groups.