COVID-19, glomerulonefritis ANCA y anti-membrana basal glomerular. Caso clínico

• Autores: Eduardo Briones, Gonzalo P. Méndez, Jorge Laguna, Miguel Vargas
• Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 150, Nº. 6, 2022, págs. 828-831
• Idioma: español
• Títulos paralelos:
  • Association of COVID-19 and glomerulonephritis with ANCA and anti-glomerular basement membrane antibodies. Report of one case
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• Resumen

  • Renal involvement in COVID-19 infection is varied and worsens its outcome and prognosis. However, the association of COVID-19 infection with glomerulonephritis is exceptional. We report a 46-year-old woman with COVID-19 who had an acute kidney injury and ANCA associated glomerulonephritis two weeks after the onset of the disease. The kidney biopsy showed a crescentic glomerulo-nephritis and the presence of anti-glomerular basement membrane antibodies (GBM-Abs). She was treated with steroids and oral cyclophosphamide with good response without requiring plasmapheresis. Plasma anti GBM-Abs were negative. This case suggests that the presence of anti-GBM-Abs in the kidney, was temporally related to COVID-19 pulmonary damage. The absence of plasma antibodies is probably due to transient production and glomerular adsorption, but with unknown pathogenic role.