Resumen de Leucemia mieloide crónica atípica BCR-ABL1 negativa: reporte de 2 casos

Fernanda Figueroa-Faúndez, Catalina Vidal-Rojas, Vania Briones-Muñoz, Mauricio Chandía-Cabas

• BCR-ABL1 negative atypical chronic myeloid leukemia (aCML) is a rare type of myeloproliferative / myelodysplastic syndrome characterized by leukocytosis and proliferation of dysplastic neutrophilic precursors in the absence of positivity for the BCR-ABL1 fusion gene. We report a 66-year-old woman and a 57-year-old man with aCML, who initially presented with general malaise and weight loss, associated with anemia, thrombocytopenia, and leukocytosis with left shift and dysplasia in the neutrophil series. Both evolved unfavorably after admission and died a few days later due to multiple organ failure.