Synthesis and antifungal activity of diaryl hydrazones from 2,4-dinitrophenylhydrazine

• SERGIO ORTIZ ; RONALD NELSON ^[1] ; VÍCTOR KESTERNICH ^[1] ; MARCIA PÉREZ-FEHRMANN ^[1] ; PHILIPPE CHRISTEN ^[2] ; LAURENCE MARCOURT ^[2]
  1. [1] Universidad Católica del Norte Departamento de Química
  2. [2] University of Geneva School of Pharmaceutical Sciences
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 61, Nº. 3, 2016, págs. 3081-3084
• Idioma: inglés
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• Resumen

  • A new series of diarylhydrazones derived from 2,4-dinitrophenylhydrazine were synthesized via condensation with aromatic aldehydes whose structures have been determined by mass spectrometry, infrared spectroscopy, and nuclear magnetic resonance spectra. Yields were 50-99%. All compounds were screened in vitro for their antifungal activity. Preliminary results indicated that compounds 3g and 3h exhibited promising antifungal potency. Understanding of the structure of these compounds establishes a preliminary structure-activity relationship to form the basis of further investigation.