Studies on the alkylation of quinolin-2(1h)-one derivatives

• CHIA-LING CHEN ^[1] ; I-LI CHEN ^[2] ; JIH-JUNG CHEN ^[2] ; DAU-CHANG WEI ^[2] ; HAN-JIE HSIEH ^[2] ; KEN-MING CHANG ^[3] ; CHERNG-CHYI TZENG ^[3] ; TAI-CHI WANG ^[2]
  1. [1] KUO General Hospital Department of Pharmacy
  2. [2] Tajen University Department of Pharmacy
  3. [3] Kaohsiung Medical University College of Life Science Departament of Medicinal and Applied Chemistry

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• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 60, Nº. 1, 2015, págs. 2812-2816
• Idioma: inglés
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  • Alkylation of quinolin-2(1H)-one (1) and its C(6) and C(7) substituted dervatives (OMe, OBn, and Cl) with 2-bromoacetophenone or chloroacetone under basic condition (K2CO3 in DMF) gave a mixture of N1- and O2- alkylated products with the former one as a major product. However, alkylation of 8-methoxy-, 8-benzyloxy-, and 8-chloro- quinolin-2(1H)-ones under the same reaction conditions gave exclusively O2-alkylated products.