Ph dependent drug delivery based on silica xerogel

• Autores: P. B. Vasconcelos, Wagner E. Silva, Mônica F. Belian
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 62, Nº. 4, 2017, págs. 3700-3702
• Idioma: inglés
• Enlaces
  • Texto completo
• Resumen

  • In this work, a matrix based on silica xerogel, synthesized from TEOS, water, ibuprofen (as template) and acetic acid at room temperature, was used for ibuprofen (IBF) incorporation, aiming to create a drug delivery system capable of releasing this compound under a basic pH condition (considering desirable and optimal release in the intestines). The IBF release was checked at different pH values (ranging from 2 to 8), using appropriate buffered solutions. After observing the IBF release performance from the silica xerogel and its dependence on the pH, the same matrix containing IBF was submitted to a novel assay, using only a pH 7 buffered solution as the best way to check the chronological release. This was carried out at 1, 2, 5 and 10 minutes to determine aliquot removal, as well as IBF concentration at each elapsed period.