Resumen de Synthesis of 5-hydroxydihydropyrimidine derivatives and the influence of intramolecular hydrogen bonding on their nmr properties and conformational preferences of the hydroxyl group
Augusto Rivera U., Ingrid Miranda-Carvajal, Jaime Ríos-Motta
A series of 2,2′-(5-hydroxydihydropyrimidine-1,3(2H,4H)-diyl)bis-(methylene)-disubstitutedphenols was synthesized by using a Mannich-type reaction between 1,3-diaminopropan-2-ol, paraformaldehyde and substituted phenols. These previously unreported compounds were separated from the reaction mixture by column chromatography (CC) in highly pure form with a 29%-91% yield. The effect of intramolecular hydrogen bonding on the conformation of 5-hydroxyhexahydropyrimidines has been studied. Our results show that the presence of hydroxyl groups can strongly influence the stereoelectronic relationships in the six-membered heterocyclic ring.
