Salicylic acid as an efficient catalyst for the diastereoselective synthesis of dispirohydroquinolines via a one-pot domino eight-component reaction

• Autores: Sajjad Salahi, Nourallah Hazeri, Malek Taher Maghsoodlou, Mojtaba Lashkari, Niloufar Akbarzadeh Torbati, Santiago García Granda, Laura Torre Fernández
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 63, Nº. 4, 2018, págs. 4159-4164
• Idioma: inglés
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• Resumen

  • Salicylic acid was used as an efficient catalyst for the diastereoselective synthesis of dispirohydroquinoline-bis (Meldrim's acid) derivatives via a one-pot domino eight-component reaction of arylamines, aromatic aldehydes and Meldrum's acid in CH3CN at room temperature. The remarkable advantages offered by this method are inexpensive catalyst, good yields, simple and easy work-up procedure. The characterization of products was done by IR, mass, 1H NMR, 13C NMR spectroscopy, and elemental analyses. The stereoselectivity of compounds was confirmed with crystallography and NMR spectroscopy.