Synthesis and crystal structure analysis of a new chalcone derivative of apocynin

• Autores: M. Zárraga, F. Rivera, P. Arroyo, A. Miranda, Ricardo Baggio, L. Álvarez, Y. Moreno
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 65, Nº. 3, 2020, págs. 4934-4936
• Idioma: inglés
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• Resumen

  • In the present report we present the synthesis and structural analysis of a chalcone derivative of Apocynin, 1-(4-hydroxy-3-methoxyphenyl)-3-(4-nitrophenyl)-2-propenone. The most characteristic feature of its molecular structure is its near-planarity, allowing molecules to be stacked in columns, at graphite intermolecular distances to each other and connected by a large variety of weak intermolecular interactions. The molecule presents structural analogies to related ones with significant pharmacological properties (e.g., Apocynin).