Improving the efficacy of magnetic nanoparticle-mediated hyperthermia using trapezoidal pulsed electromagnetic fields as an in vitro anticancer treatment in uveal melanoma and glioblastoma multiforme cell lines

• Souiade, Lilia ^[1] ; Domingo Diez, Javier ^[1] ; Alcaide León, César ^[1] ; Ramos Gómez, Milagros ^[1] ; Serrano Olmedo, José Javier ^[1]
  1. [1] Universidad Politécnica de Madrid

     Universidad Politécnica de Madrid

     Madrid, España

     
• Localización: CASEIB 2023. Libro de Actas del XLI Congreso Anual de la Sociedad Española de Ingeniería Biomédica: Contribuyendo a la salud basada en valor / coord. por Joaquín Roca González, Dolores Ojados González, Juan Suardíaz Muro, 2023, ISBN 978-84-17853-76-1, págs. 140-143
• Idioma: inglés
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• Resumen

  • Magnetic hyperthermia (MHT) is a novel cancer treatment that utilizes magnetic nanoparticles (MNPs) to generate localized heat under low frequency alternating magnetic field (AMF). Recently, trapezoidal pulsed alternating magnetic fields (TPAMF) have proven their capability in enhancing the efficiency of heating in MHT as compared to the sinusoidal one.. Our study aims to compare TPAMF waveform’s killing effect against the sinusoidal waveform in B16F10 and CT2A cell cultures to determine more efficient waveforms in causing cell death. For that purpose, we used SPIONs (superparamagnetic iron oxide nanoparticles) at 1 and 4 mg/ml with four different AMF waveforms: three non-sinusoidal, namely trapezoidal (TP), almost-square (TS) and triangular (TR), and the sinusoidal signal (SN). Among the explored cases, the non- harmonic signals demonstrated better efficacy than the SN one as MHT treatment. After MHT treatments, B16F10 cells incubated with SPIONs at 1 ...