Resumen de Determinación de las características clínico-epidemiológicas de la neuroinfeccción en pacientes con diagnóstico de VIH/sida en el departamento del Quindío

Jhon Carlos Castaño-Osorio, Gregorio Sanchez Vallejo, David Franco Andrew, María Mercedes González-De Schroeder, Alejandra María Giraldo-Garcia

• español

  Objetivo general. Describir las características clínico-epidemiológicas y etiológicas de la neuroinfecciónde los pacientes con VIH del departamento delQuindío. Materiales y métodos. Se realizó un estudiode tipo descriptivo prospectivo de los pacientescon VIH y sospecha de neuroinfección de unaEmpresa Social del Estado de tercer nivel de Armenia.En el departamento del Quindío no se han reportadoprotocolos diagnósticos que correlacionenel costo-beneficio de los diferentes esquemas demanejo pacientes con VIH y una infección asociadadel sistema nervioso central.Todos los pacientes que consultaron a la EmpresaSocial del Estado de tercer nivel de Armeniacon dos pruebas positivas de ELISA anti-VIH o unaprueba de Western blot positiva, con sospecha deenfermedad del sistema nervioso central concomitante.

• English

  Objective: To describe clinical, epidemiological and etiological characteristics of neuroinfection in HIV patients from Quindío department.Materials and methods: A descriptive-prospective study was carried out in HIV positive patients with neuroinfection suspicion from a third level ESE of Armenia.In Quindío department have not been reported diagnostic protocols that correlate the cost-benefit of the various schemes of handling patients with HIV infection associated with the central nervous system (CNS).All the patients that consulted the third level ESE of Armenia with two positive anti-HIV ELISA tests or positive a Western Blot test with suspicion of concomitant CNS illness. The following laboratory tests were performed in cerebrospinal fluid (CSF): VDRL, Chinese ink, Ziehl-Nielsen stain, fungi cultures, CMV and Herpes simplex PCR, serum IgG anti-Toxoplasma, and Cryptococcal Antigen Latex Agglutination System (CALAS); a simple cerebral CT scan was taken to all patients.Results: 85.7% of the patients were men; the age rank was between 23 and 68 years. The most frequently found symptoms were: fever, consciousness and orientation compromise, paresis, paresthesia, cranial pairs compromise, and altered neurological reflexes.89% of the patients with brain space occupying lesions were IgG anti-Toxoplasma positive( values between 155 and 887.2 UI/ml) and the antibodies values in patients without cerebral lesion in the simple cerebral CT scan oscillated between 13.8 and 36 UI/ml.Discussion: Simple cerebral CT scan, serum IgG anti-Toxoplasma and staining of CSF with Chinese ink allowed the diagnosis of 85% of the patients.